Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells
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Assessment and pharmacological correction of abnormalities in bicarbonate (HCO3-) and mucus transport in intestinal biopsies and organoids of CF patients
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Evaluation of the biological and therapeutic properties of mesoangioblasts-vessel associated progenitor cells- in the cell based therapy of the cystic fibrosis disease
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A kinase-directed approach to rescue functionality of F508del CFTR
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Novel aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis: computer assisted drug design, synthesis and biological evaluation
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A CF IL-8 transgenic mouse model for the in vivo long-term monitoring of the anti-inflammatory role of metallo-protease inhibitors and antibiotics with mechanisms of action similar to that of azithrom
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Development and preclinical testing of a novel antimicrobial peptide to treat Pseudomonas aeruginosa-induced lung infections
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Anti-inflammatory and anti-bacterial activity of bovine lactoferrin administered by aerosol in airway infections of pre-clinical wt and CF mouse
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Targeting extracellular protein disulphide isomerase to control Burkholderia cenocepacia lung infections
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Role of small RNA-based regulatory systems in cystic fibrosis airways infection by Pseudomonas aeruginosa: a new frontier in the identification of molecular targets for novel antibacterials
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Investigating the airway microbiome in cystic fibrosis patients with a severe decline in lung function: an opportunity for a personalized microbiome based therapy
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GSH inhalation therapies in CF: how useful, how safe? Set-up of a CF murine model for monitoring of inflammation in vivo and assessment of convenient alternatives
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Development of metallo-enzyme inhibitors to overcome Pseudomonas aeruginosa antibiotic-resistance in cystic fibrosis patients
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Mitochondrial Ca2+-dependent inflammasome activation exacerbates the P. aeruginosa-driven inflammatory response
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Identification and characterization of LPS-neutralizing human peptides: potential tools to control inflammation in cystic fibrosis lung disease
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A systems biology approach to the correction of Cystic Fibrosis: from building a network of proteostasis regulatory pathways to combinatorial targeting
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