Background.The possibility of monitoring the inflammatory response in a IL-8 transgenic WT and CFTR knockout (CF), non invasive, animal model has been demonstrated in a previous project conducted by us [1, 2]. 

Hypothesis and objectives In the past project we shown that the antibiotic azithromycin causes a significant decrease of the lung inflammation in that is capable of inhibiting the synthesis of bacterial virulence factors. Azithromycin is extensively used in cystic fibrosis as an anti-inflammatory molecule but several cases of azithromycin resistance have been reported [1-2], especially in patients using the drug for long times. It seems then important to identify other therapeutic agents to be used in nonresponding patients.