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Role of small RNA-based regulatory systems in cystic fibrosis airways infection by Pseudo
     
 
Author(s) : Ferrara S, Macchi R, Falcone M, Rossi A, Ranucci S, Bragonzi A, Cigana C, Bertoni G
Address : Department of Biosciences, Università degli Studi di Milano, Milan, Italy, Infections and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy 
Università degli Studi di Milano, San Raffaele Scientific Institute
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Background. The comprehension of molecular mechanisms underlying CF airways infection by Pseudomonas aeruginosa is instrumental to the design of clinical protocols to prevent and contrast it. Emerging candidates as molecular regulators of infection and virulence in P. aeruginosa are small RNAs (sRNAs), which in other bacterial pathogens have been shown to play key roles in modulating cellular processes linked to pathogenesis. 

Hypothesis and objectives. From this perspective, the main aim of this project was the evaluation of the impact on P. aeruginosa virulence and infection of three new sRNAs recently identified in our lab and named ErsA, ReaL and PesA. 

 
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