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TRPA1 channels as novel molecular targets for anti-inflammatory therapies in CF lung
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Author(s) : Prandini P, De Logu F, Fusi C, Provezza L, Nassini R, Montagner G, Materazzi S, Munari S, Gilioli E, Bezzerri V, Finotti A, Lampronti I, Tamanini A, Dechecchi MC, Lippi G, Ribeiro CM, Rimessi A, Pinton P, Gambari R, Geppetti P, Cabrini G
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Address : University Hospital of Verona, Italy, University of Florence, Italy; University of Ferrara, Italy; Marsico Lung Institute and University of North Carolina, Chapel Hill, NC, U.S.A. LTTA of the University of Ferrara, Italy.
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Multiple Institutions in collaboration
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Info@PostdocJournal.Com
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Background. Pseudomonas aeruginosa colonization, prominent inflammation with massive expression of the neutrophil chemokine IL-8 and luminal infiltrates of neutrophils are hallmarks of chronic lung disease in Cystic Fibrosis (CF) patients. The nociceptive Transient Receptor Potential Ankyrin 1 (TRPA1) calcium channels have been recently found involved in non-neurogenic inflammation.
Hypothesis and objectives. TRPA1 channels could be involved in the pro-inflammatory signaling pathways activated in CF airway epithelial cells infected by P. aeruginosa. The principal objective is to verify whether TRPA1 channels could be relevant molecular targets for innovative anti-inflammatory therapies in CF patients.
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