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Cystic fibrosis modifier genes related to Pseudomonas aeruginosa lung disease
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Author(s) : Lorè NI, Sipione B, Mott R, Iraqi F, Bragonzi A
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Address : Infection and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS - San Raffaele Scientific Institute, Milan, Italy, Division of Biosciences, UCL Genetics Institute, London, England, Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Multiple Universities in collaboration
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Info@PostdocJournal.Com
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Background. The remarkable heterogeneity among CF patients in the time of onset as well as in the severity of P. aeruginosa lung disease raised the question whether other genetic loci in addition to the CFTR can contribute to the clinical variation. Recently, Collaborative Cross (CC) mouse population has been generated as an innovative and powerful source to model the diversity of the human population.
Hypothesis and objectives. By using the CC lines as a novel and high genetically diverse mouse resource population, this project aims to identify genetic factors that may influence the severity of P. aeruginosa respiratory infections in CF.
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