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    ISSN : 2328-9791
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In vitro study of potential pro-fibrotic effect of Everolimus in different human airway c
     
 
Author(s) : Tomei P, Masola V, Granata S, Chilosi M, Lupo A, Zaza G
Address : Renal Unit, Department of Medicine, University of Verona, Department of Pathology and Diagnostics, Laboratory of Molecular Pathology, University-Hospital of Verona, Italy.
University of Verona; University-Hospital of Verona, Italy
Info@PostdocJournal.com

Background. MTOR-inhibitors (mTOR-I), Everolimus (EVE) and Sirolimus, immunosuppressants broadly used in transplantation, may determine severe adverse events including pulmonary fibrosis.

Hypothesis and objectives. The pathogenic mechanism of mTOR-I-associated pulmonary toxicity is still unclear, but epithelial to mesenchymal transition (EMT) of bronchial/pulmonary cells may have a role.

 
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