a Journal of Postdoctoral Research and Postdoctoral Affairs.
    ISSN : 2328-9791
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Cystic fibrosis and meconium ileus: a multicentric study on risk factors for adverse outcome in infancy
Author(s) : Padoan R, Cesana B, Falchetti D
Address : Centro Regionale di Supporto per la Fibrosi Cistica
Medicina e Chirurgia, Università di Brescia
Chirurgia Pediatrica, H Niguarda Ca’ Granda, Milano, Italy

Background. Meconium ileum (IM) is recognized as a risk factor for worse growth in early years in Cystic Fibrosis (CF) CF, as demonstrated by a previous 0-12 month population diagnosed for neonatal screening positivity (FFC 19/2012). We do not yet have epidemiological data or clinical information on early life and on clinical follow-up for Italian CF patients with IM. We suggest that risk factors associated to poor clinical outcomes might be identified in patients with MI, and eventually they might be modifiable. The first aim of the study is to identify risk factors associated to poor clinical outcomes in the first year of life in MI infants. Secondary aim is to describe complications presented in early age. 

Methods. Subjects with IM who were born in the years 2009-2015 were enrolled, followed in 13 FC Centers. A database was built for the collection of data: diagnosis of ileum, surgical history, (IM medical or surgical, simple or complex), CF diagnosis data, medical and surgical treatments, anthropometric data and follow up from zero to 12 months. Negative outcome was the failure to grow and/or chronic Pseudomonas infection at 1 year, death. Some variables evaluated as possible risk factors for an adverse outcome are: presence of IM, complicated IM, presence of stoma, duration of the first hospitalization, parenteral nutrition, age at CF specialist visit. 


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