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    ISSN : 2328-9791
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Establishment of single-cell and animal model to investigate pathogenesis of infection by Mycobacterium abscessus complex members in cystic fibrosis
     
 
Author(s) : Tortoli E, Riva C, Gona F, Bragonzi A, Cigana C, Rossi M, Cirillo DM
Address : Pathogens Unit, IRCCS, and Infections and Cystic Fibrosis Unit, IRCCS, San Raffaele Scientific Institute, Milano, Italy.
flaminia.malvezzi@fibrosicisticaricerca.it

Background and rationale. M. abscessus (MA) is one of the most frequently isolated non tuberculous mycobacteria (NTM) in patients with cystic fibrosis (CF). Despite the increasing reports on prevalence of MA, including multidrug resistant strains, its pathogenic role is still controversial, due to the limitations of the available cellular and animal models used to study MA infection. 

Hypothesis and objectives. Our hypothesis is that strains of MA isolated from patients with deteriorated lung functionality may differ in pathogenicity from the ones isolated from asymptomatic patients. For this reason we established a murine model of chronic lung infection to investigate the pathogenicity of the MA subspecies (sspp) and identify the patients who could benefit from antimicrobial treatment.

 
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