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a Journal of Postdoctoral Research and Postdoctoral Affairs.
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    ISSN : 2328-9791
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Role of small RNA-based regulatory systems in cystic fibrosis airways infection by Pseudomonas aeruginosa: a new frontier in the identification of molecular targets for novel antibacterials
     
 
Author(s) : Ferrara S, Macchi R, Falcone M, Rossi A, Ranucci S, Bragonzi A, Cigana C, Bertoni G
Address : Universit√† degli Studi di Milano, Milan, Italy, And Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy 
flaminia.malvezzi@fibrosicisticaricerca.it

Background and rationale. In the field of CF airways infection by Pseudomonas aeruginosa, the comprehension of molecular mechanisms underlying the infection process is crucial to the design of new clinical protocols to prevent and contrast it. Anti-virulence therapies have become an attractive approach that may yield drugs with high specificity and narrow spectra, and in this perspective bacterial small RNAs (sRNAs) represent a largely unexploited category of potential targets for anti-virulence design. Interestingly, sRNAs have been shown to play key roles not only in modulating bacterial virulence but also microbial processes leading to antibiotic resistance. 

 
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